This report is an analysis of discussions and presentations that took place at the ‘Locating the Power of In-between’ conference in Pretoria, South Africa in July 2008. The conference was organised to shine a spotlight on the role of research brokers, knowledge and information intermediaries and info-mediaries, and the contribution they can make insupporting and enabling evidence-based, pro-poor policy and practice. This report identifies key issues from the conference and presents them for further analysis, discussion and action by people undertaking intermediary work, their stakeholders and those interested in information and communication flow around pro-poor policy and practice. It draws out key points of the realities of evidence-based policy, where intermediaries fit into that contextand ideas about how intermediaries can contribute and challenge their work. In conclusion, it points to future action, in particular, the need for collaboration between intermediary actors, to step up to the challenges identified. The organizers hope that by starting a debate, illustrating a range of intermediary activities, forming connections between people and providing the basis for future analysis, the conference and this report will inspire action that will enable intermediaries to reach their full potential as development actors in their own right.